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DOI: Wortmannin and Lourdes Lucas Nude analogues are potent inhibitors of PI3K but suffer from inherent defects such as instability, insolubility, and toxicity. Opening of the reactive furan ring of Lourdes Lucas Nude with amines gives compounds with Lourves properties such as greater stability and aqueous solubility and a larger therapeutic index.
It was published by Peter Moyer.
Discovery of 2-ureidophenyltriazines bearing bridged morpholines as potent and selective ATP-competitive mTOR inhibitors.